“Multicellular life of Pseudomonas putida: from metabolic signals to global regulators”

Research in the Espinosa laboratory is related with Pseudomonas putida biofilms on abiotic and plant surfaces; mechanisms, signals and evolution.

“Role of respiratory NADH oxidation in the regulation of Staphylococcus aureus virulence”

The goal of Lici Schurig-Briccio is the study of the structure and mechanism of prokaryotic respiratory enzymes that generate a membrane potential

“Bacterial responses to high environmental phosphate concentration: physiological aspects and potential biotechnological applications” 

Rapisarda´s group aim is to elucidate the mechanisms of action and cellular processes that are triggered in microorganisms by exposure to different environmental conditions. Their work is both in the field of basic and applied research, and it has a considerable public and regional interest

"DNA sequence diversity of the minicircle hypervariable region of  

Trypanosoma cruzi".

His research is centered in the molecular epidemiology of Chagas disease and in genetic and phylogenetic aspecs of Trypanosoma cruzi.

"Structural basis of glycogen biosynthesis regulation in bacteria"

His research is focused in the structural determinants and the modulation of substrate specificity of carbohydrate active enzymes. His work employs a multidisciplinary approach including X-ray crystallography, X-ray rree electron laser (XFEL), Cryo electron microscopy (Cryo-EM), protein biophysics, protein biochemistry and molecular biology, to elucidate mechanistic aspects of these processes at the molecular level.

"Epigenetic-microRNA circuitry regulating neural crest delamination and condensation"

His research is related with the epigenetic control of cell differentiation during vertebrate development.  His principal lines of research are related to:

a) the epigenetic regulation and microRNA during the delamination and condensation of cells from the neural crest and  

b) the transgenerational epigenetic effect of folic acid defficiency during vertebrate embryonic development.

 "Shedding light on the role of histone chaperones during DNA damage after UV-B exposure in plants"

Research in the Casati`s lab focuses on responses to UV-B in plants. Complex physiological changes occur in plants that modulate gene expression and consequently phenotypes in response to the radiation. One of her objectives is to study the role of chromatin in the repair of DNA damage by UV

“The proteome dark matter: on the origin of neogenes and neoproteins”
The Marazzi Laboratory studies epigenetic and chromatin-mediated control of gene expression in the context of the cellular response to pathogens or differentiation. They use biochemistry, genetics, and next generation sequencing techniques to understand molecular mechanisms and genome-wide effects of known and novel candidate genes. 

EMBO YOUNG INVESTIGATOR LECTURE
“Epigenome maintenance in response to DNA damage”
The research in her laboratory focuses on identifying the molecular agents that control the dynamics of histones and alterations in the structure and function of chromatin in response to genotoxic stress

"Mechanism of organelle identity within  the endolysosomal pathway”

The goal of the Ungermann laboratory is to define the mechanism of organelle identity of endosomes and lysosomes using mainly yeast (S.cerevisiae) as a model system.

“The VPS13 family of lipid transport proteins”

Dr. Conibear studies the molecular machinery of human cellular transportation system and the traffic jams that cause disease. Her lab focuses on lipid and protein signaling pathways involved in neurological disorders like Alzheimer’s disease and lysosomal storage diseases that affect childhood development.    

“Sorting without a Golgi complex: the endoplasmic reticulum as the sorting core facility in the protozoan Giardia lamblia"

Her research field is the study of the molecular mechanisms involved in the vesicular traffic, to the lysosome-type vacuoles in the intestinal parasite Giardia lambia. Particularly, her work describes de machinery formed  by adaptor proteins and clathrin in the transport of lysosomal hydrolases.

“ In silico testing the fundamental mechanisms and logic of intracellular traffic"

His laboratory is interested in the mechanisms of intracellular transport in different experimental models. One characteristic of the group has been the design of new experimental and theoretical tools to approach endosomal and exocytic processes from unexplored perspectives

"Membrane modeling during endosomal sorting "

Her research focuses on the regulation of vesicle trafficking mechanisms in plant cells. Her goal is to understand how cells control the flow of proteins and specialized metabolites between different cellular compartments 

"Emerging roles of PILS intracellular auxin transport facilitators in plant growth and development"

Her research aim is the phytohormonal control of cellular growth: Auxin-dependent growth regulation on subcellular, cellular, tissue and organ level 
 

"Unraveling plant vacuolar trafficking through forward genetics, a recipe for surprises"

Plants adjust their development to accommodate cell differentiation and growth to fluctuating environmental conditions. Intricate signalling networks translate environmental cues into reprogramming of gene expression as a major adaptive response to biotic and abiotic stresses. His lab aim is to study the signalling networks in plant development and defense responses. 

"Inverse modulation of antiviral and antibacterial immunity by transmembrane immune receptors"

She will report that the receptor-like kinase NIK1, which was previously shown to positively regulate plant antiviral immunity, acts as an important negative regulator of antibacterial immunity. The proposed underlying mechanism for NIK1-mediated inverse modulation of antiviral and antibacterial immunity may allow bacteria and viruses to activate host immune responses against each other.

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“Regulation of sphingosine-1-phosphate and its role for chronic inflammation and carcinogénesis”

His interest is focused on chronic inflammation, inflammation-driven carcinogenesis, dendritic cell signaling and function, chemokines and immune modulation by sphingolipids

"Mapping lipid alterations in amyotrophic lateral sclerosis through lipidomic analysis"

Currently the research in her laboratory is focused on the investigation of oxidized products formed from polyunsaturated fatty acids, in particular the docosahexaenoic acid (DHA, omega-3) present in large quantities in the brain. Her goal is to identify and quantify DHA oxidation / modification products in neurodegenerative diseases

 "Biosynthesis of Sphingolipids with very-long-chain PUFA: a hallmark in differentiating male germ cells"

His interest is related with the search of strategies for the development and study of in vitro spermatogenesis: role of the lipids with polyunsaturated fatty acids

"Role of lipid-membrane protein interactions revealed by mass spectrometry and molecular dynamics simulations"

His research is related to the structure and function of membrane proteins, in particular, determining how structural interactions between these proteins can trigger a molecular and cellular "cross-talk". This task is essentially multidisciplinary and therefore requires a combination of different methods including the development of new theoretical, structural and functional approaches

“Translation affects mRNA stability in a codon dependent manner in human cells and Zebrafish embryos”  

His current focus is on the regulation of gene expression in vertebrates. Bazzini’s contribution to this research field has included the first clear demonstration of the kinetics of microRNA (miRNA) molecules in the in vivo regulation of gene expression in the zebrafish model system 

"Fragmentation of extracellular ribosomes and tRNAs shapes extracellular small RNA profiles”

The focus of his current research activities is on the extracellular biology of these regulatory RNAs, and their ability to work as signaling molecules between cells. 

"Dynamics and functional relevance of ribonucleoproteic membrane-less organelles"

Her work is related on translational regulation. Her aim is to study how the Processing Bodies (PBs), the Stress Granules (SGs), and related bodies are involved in translational regulation in neuros, specifically at the post-synapse, where thousands of mRNAs are localized and presumably regulated by synaptic stimulation thus helping synapse plasticity 

"Short stories on RNA biogenesis in mammalian cells"

Her laboratory studies the connection between the splicing process and the SUMO conjugation pathway. They revealed a novel role for a well-known splicing factor, SRSF1, as a regulator of protein SUMOylation. Furhtermore, they have recently found that SUMO conjugation to spliceosomal proteins influences splicing efficiency both in vitro and in cultured mammalian cells. 

"Angel2, a member of the CCR4-NOT family of deadenylases, is a mammalian  2’,3’-cyclic phosphatase "

Our focus is on non-canonical RNA splicing found in two essential mammalian pathways, pre-tRNA splicing and the Unfolded Protein Response (UPR), and the uncommon 2’,3’-cyclic phosphate ended RNAs intermediates found therein.